Exosomes in Aesthetic Medicine
How Dermatologists & Plastic Surgeons Are Using Them to Enhance Results
Exosomes are nano-sized extracellular vesicles (30–150 nm) that transport proteins, microRNAs, and lipids between cells to regulate inflammation, repair, and regeneration.¹ Their ability to modulate cellular behavior positions them as a powerful tool in aesthetic medicine, especially when used as adjuncts to in-office procedures.
Three Ways Exosomes Are Used in Aesthetic Dermatology & Cosmetic Medicine
1. Exosomes for Skin Rejuvenation & Anti-Aging
Exosomes communicate directly with fibroblasts and keratinocytes to support collagen production, elastin formation, and more balanced inflammatory responses.² When applied after microneedling, RF microneedling, fractional lasers, or chemical peels, exosomes may help patients experience:
Speedier recovery with reduced erythema
Improved hydration and skin barrier function
Smoother texture and refined pores
Visible improvements in tone and fine lines
Clinical observations and early studies suggest exosomes may enhance tissue remodeling when used in conjunction with energy devices.³
2. Exosomes as Adjuncts to Microneedling & Laser Procedures
Exosomes have become especially popular as a post-procedure serum because the micro-channels created by microneedling significantly enhance delivery.
Potential clinical advantages include:
Enhanced collagen remodeling
Reduced downtime and quicker re-epithelialization
Support for healthier, more robust healing
Evidence suggests they may amplify the regenerative cascade triggered by controlled skin injury.⁴
3. Exosomes for Hair Regrowth & Scalp Health
Exosomes used in scalp treatments may stimulate hair follicle activity by influencing pathways associated with:
Dermal papilla cell proliferation
Wnt/β-catenin activation
Increased anagen (growth) phase duration
Emerging case series demonstrate increases in density and shaft thickness in androgenetic alopecia when exosomes are combined with microneedling.⁵ ⁶
Risks, Limitations & Safety Considerations
While generally well tolerated when used topically, exosome therapy carries important considerations:
Product variability: Source and manufacturing standards differ widely. Full Dose is an authorized wholesaler of Ascellos exosomes.
Lack of standardization: Potency and purity vary across brands. Choose wisely.
Inflammatory or immunologic reactions: Although possible due to bioactive cargo, many providers believe these reactions are unlikely.
Practices should use only well-characterized, reputable products and educate patients about the experimental nature of these treatments.
FDA Position on Exosomes
As of 2025, the FDA has not approved any exosome products for medical or cosmetic use.⁷ ⁸ Key takeaways for aesthetic providers include:
Injectable exosomes are considered unapproved biologics unless used in an FDA-authorized clinical trial.
Topical exosomes marketed with claims that affect skin structure or function may be classified as unapproved drugs.
FDA has issued multiple safety notifications and warning letters regarding unapproved exosome products.⁷
Practices should ensure marketing language and consent forms reflect the current regulatory status. The next logical consideration is: how to use exosomes compliantly and practically?
How to Integrate Exosomes Ethically & Effectively in Your Practice
Pair exosomes with microneedling, RF, or lasers as a recovery-supporting topical.
Use transparent informed consent explaining benefits, limitations, and FDA status.
Choose high-quality, well-characterized suppliers with robust data and quality controls.
Avoid unsubstantiated claims; focus on supporting skin wellness and recovery, not treating disease.
Exosomes are one of the most promising biologic adjuncts in aesthetic medicine today. While evidence continues to grow, they already offer exciting potential for skin rejuvenation, hair restoration, and improved post-procedure outcomes—when used responsibly and within regulatory guidelines.